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Experiment and Theory in Modern Biology Course 2008


THURSDAYS 2-4PM (Weiss 17 East)

1. September 11, 2008

Luria, S., and Delbruck, M. (1943). Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28: 491-511. [PDF]

Muller, H.J. (1927). Artificial transmutation of the gene. Science 66: 84-87. [PDF]

2. September 18, 2008

Meselson, M., and Stahl, F. (1958). The replication of DNA in E. coli. Proc. Natl. Acad. Sci. USA 14: 671-682. [PDF]

Okazaki, R., Okazaki, T., Sakabe, K., Sugimoto, K., and Sugino, A. (1968). Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains. Proc. Natl. Acad. Sci. USA 59: 598-605. [PDF]

3. September 25, 2008 NOTE: Student presentations start this week.

Nirenberg, M.W., and Matthaei, J.H. (1961). The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. Proc. Natl. Acad. Sci. USA 47: 1588-1602. [PDF]

Dintzis, H.M. (1961). Assembly of the peptide chains of hemoglobin. Proc. Natl. Acad. Sci. USA 47: 247-261. [PDF]

4. October 2, 2008

Jacob, F., and Monod, J. (1961). Genetic Regulatory Mechanisms in the Synthesis of Proteins. J. Mol. Biol. 3: 318-356. [PDF]

Lingappa VR, Katz FN, Lodish HF, Blobel G. (1978) A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. J Biol Chem. 253(24): 8667-8670. [PDF]

October 9, 2008

NO MEETING-YOM KIPPUR HOLIDAY

October 16, 2008

NO MEETING

5. October 23, 2008

Stehelin, D., Varmus, H.E., Bishop, J.M, and Vogt, P.K. (1976). DNA related to transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260: 170-173. [PDF]

Eliyahu, D., Raz, A., Gruss, P., Givol, D., and Oren M. (1984). Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature 312: 646-649. [PDF]

6. October 30, 2008

Botstein, D., White, R.L., Skolnick, M., and Davis, R.W. (1980). Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32: 314-331. [PDF]

The Huntington's Disease Collaborative Research Group. (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72: 971-983. [PDF]

7. November 6, 2008

Prusiner, S.B., Scott, M., Foster, D., Pan, K.M., Groth, D., Mirenda, C., Torchia, M., Yang, S.L., Serban, D., Carlson, G.A., Hoppe, P.C., Westaway, D., and DeArmond, S.J. (1990). Transgenetic studies implicate interactions between homologous PrP isoforms in Scrapie prion replication. Cell 63: 673-686. [PDF]

Wickner, R.B. (1994). [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae. Science 264: 566-569. [PDF]

8. November 13, 2008

Novick, P., and Schekman R. (1979). Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U S A. 76: 1858-1862. [PDF]

Fries, E., and Rothman, J.E. (1980). Transport of vesicular stomatitis virus glycoprotein in a cell-free extract. Proc. Natl. Acad. Sci. U S A. 77: 3870-3874. [PDF]

9. November 20, 2008

Brack, C., Hirama, M., Lenhard-Schuller, R., and Tonegawa S. (1978). A complete immunoglobulin gene is created by somatic recombination. Cell 15: 1-14. [PDF]

Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J., and Hoffman, J.A. (1996). The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults. Cell 86: 973-983. [PDF]

November 27, 2008

NO MEETING-THANKSGIVING HOLIDAY

10. December 4, 2008

Quinn, W.G., Harris, W.A., and Benzer, S. (1974). Conditioned Behavior in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 71: 708-712. [PDF]

Konopka, R.J., and Benzer, S. (1971). Clock Mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 68: 2112-2116. [PDF]

11. December 11, 2008

Lolle, S.J., Victor, J.L., Young, J.M., and Pruitt, R.E. (2005). Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis. Nature 434: 505-509. [PDF]

Rutherford, S.L., and Lindquist, S. (1998). Hsp90 as a capacitor for morphological evolution. Nature 396: 336-342. [PDF]

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